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Adjective: up the creek
Usage: informal
  1. In trouble or difficulty
    - in the soup [informal], in deep water [informal], in hot water [informal], up against it [informal]

Nearest

up for grabs
up front
up here
up in arms
up in the air
up on
up quark
up shit creek
up sticks
up the ante
up the creek
up the duff
up the spout
up the stairs
up the stick
up to
up to date
up to her neck
up to his neck
up to my neck
up to now