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Adjective: up against it
Usage: informal
  1. In trouble or difficulty
    - up the creek [informal], in the soup [informal], in deep water [informal], in hot water [informal]

Nearest

unwrap
unwrapped
unwrinkled
unwritten
unwritten law
unyielding
unyieldingness
unyoke
unzip
up
up against it
up and down
up for
up for grabs
up front
up here
up in arms
up in the air
up on
up quark
up shit creek