1. Unaware as a result of being uninformed
   "He felt completely out of it during the technical discussion"
    
2. Excluded from an activity or social group
   "He felt out of it when his friends discussed a movie he hadn't seen"
    
3. Unresponsive to stimulation
   "he lay out of it where he had fallen";
   - insensible, senseless
    
4. [Brit, informal] Very drunk
   "I had travelling money and got out of it in the bar downstairs";
   - besotted [archaic], blind drunk [informal], blotto [informal], crocked [N. Amer, informal], cockeyed [informal], fuddled [informal], loaded [N. Amer, informal], pie-eyed [informal], pissed [Brit, informal], pixilated [informal], plastered [informal], sloshed [informal], smashed [informal], soaked [informal], soused [informal], sozzled [informal], stiff [informal], tight [informal], wet [informal], drunk, bombed [informal], three sheets to the wind [informal], off one's face [Brit, informal], pickled [informal], stinko [informal], fried [N. Amer, informal], legless [Brit, informal], blootered [UK, dialect], paralytic [Brit, informal], stewed [informal], liquored up [N. Amer], swacked [N. Amer, informal], steaming [informal], trashed [informal], trolleyed [Brit, informal], bladdered [Brit, informal], mullered [Brit, informal], trollied [Brit, informal], tanked up [informal], screwed [informal], lit up [slang], wasted [informal], hammered [informal], blitzed [informal], stonkered [Austral, NZ, informal], juiced [N. Amer, informal], wrecked [Brit, informal], bevvied [Brit, informal], pixillated, half-seas-over [Brit, informal]

See also: drunk, gone, incognisant [Brit], incognizant, inebriate, inebriated, intoxicated, ripped [informal], skunked [informal], unaware, unconscious, unwanted