1. Confuse or disorient completely
   "The plot twist completely discombobulated the audience";
   - bewilder, bemuse, throw
    
2. Confuse or leave at a loss because of something complex or difficult to understand
   "These questions discombobulate even the experts";
   - confuse, throw, fox, befuddle, fuddle, bedevil, confound, perplex, vex, stick, get, puzzle, mystify, baffle, beat, pose, bewilder, flummox, stupefy, nonplus, gravel, dumbfound

Derived forms: discombobulated, discombobulates, discombobulating

Type of: affect, bear on, bear upon, discomfit, discompose, disconcert, impact, untune [rare], upset