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1. Confuse or leave at a loss because of something complex or difficult to understand
   "These questions perplex even the experts";
   - confuse, throw, fox, befuddle, fuddle, bedevil, confound, discombobulate [informal], vex, stick, get, puzzle, mystify, baffle, beat, pose, bewilder, flummox, stupefy, nonplus, gravel, dumbfound
    
2. Make more complicated
   "There was a new development that perplexed the matter";
   - complicate

Derived forms: perplexing, perplexes, perplexed

Type of: alter, be, change, modify

Antonym: simplify

Encyclopedia: Perplex