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Adjective: viperous  vI-pu-rus
  1. Marked by deep ill will; deliberately harmful
    "Her viperous comments hurt everyone around her";
    - poisonous, venomous, vicious, malicious
     
  2. Of, pertaining to, or resembling a viper
    "The snake's viperous head was triangular in shape";
    - viperine
     
  3. Malicious or spiteful
    "He gave a viperous look before storming out of the room";
    - viperine

See also: beady-eyed, bitchy [informal], cattish [informal], catty [informal], despiteful [archaic], leering, malevolent, spiteful, venomed, vindictive, vixenish