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Adjective: unwholesome  ,ún'hówl-sum
  1. Harmful or detrimental to physical, mental, or moral well-being
    "unwholesome food and living conditions"

See also: harmful, insalubrious, insubstantial, morbid, nauseating, nauseous, noxious, queasy, rich, sickening, unhealthful [rare], unhealthy, unsound, vomitous [US]

Antonym: wholesome