1. (computing) the bit in a multiple-bit binary number with the largest value; this is usually the bit farthest to the left, or the bit transmitted first in a sequence. For example, in the binary number 1000, the MSB is 1, and in the binary number 0111, the MSB is 0
   "In digital signal processing, the most significant bit often carries crucial information";
   - MSB

Derived forms: most significant bits

Encyclopedia: Most significant bit