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Noun: fly in the ointment
  1. An inconvenience that detracts from the usefulness of something

Type of: inconvenience, troublesomeness, worriment [US, informal]

Encyclopedia: Fly in the ointment

Nearest

fly by
fly casting
fly contact
fly floor
fly frame
fly front
fly gallery
fly high
fly honeysuckle
fly in the face of
fly in the ointment
fly in the teeth of
fly off the handle
fly on
fly on the wall
fly open
fly orchid
fly poison
fly press
fly rod
fly sheet