1. Regardless of, in defiance of
   "went shopping despite the bad weather";
   - in spite of, notwithstanding, in the face of

1. Lack of respect accompanied by a feeling of intense dislike
   "the despite in which outsiders were held is legendary";
   - contempt, disdain, scorn
    
2. Contemptuous disregard
   "she wanted neither favour nor despite"

Derived forms: despites

Type of: dislike, disregard, neglect

Encyclopedia: Despite