1. Capital and largest city in South Carolina; located in central South Carolina
   - capital of South Carolina
    
2. A North American river; rises in southwestern Canada and flows southward across Washington to form the border between Washington and Oregon before emptying into the Pacific; known for its salmon runs in the spring
   - Columbia River
    
3. A town in west central Tennessee
    
4. A university in New York City
   - Columbia University
    
5. A university town in central Missouri

Sounds like: Colombia

Type of: river, school [N. Amer], state capital, town, uni [Brit, informal], university

Part of: Big Apple [informal], Canada, Evergreen State, Gotham [US, informal], Great White North [N. Amer], Greater New York, Ivy League, Missouri, MO, Mo., New York, New York City, NYC, Palmetto State, S.C., SC, Show Me State [informal], South Carolina, Tenn., Tennessee, TN, Volunteer State, WA, Wash., Washington

Encyclopedia: Columbia, SC metropolitan area