1. [Brit, informal] Having detailed knowledge, and the skills to use it effectively
   "The clued-up receptionist was surprisingly well-informed about company procedures";
   - intelligent, well-informed, savvy [informal]
    
2. Up to date with the latest developments
   "He's pretty clued-up when it comes to new technology";
   - well-informed, in touch, plugged in [informal], switched on [informal]

See also: sophisticated